abstract：:The closed-die compaction behaviour of D-mannitol granules has been simulated by the discrete element method (DEM) to investigate the granule rearrangement and fracture behaviour during compaction which affects the compactibility of the tablet. The D-mannitol granules produced in a fluidized bed were modelled as agglo...

journal_title：AAPS PharmSciTech

authors： Furukawa R,Kadota K,Noguchi T,Shimosaka A,Shirakawa Y

更新日期：2017-08-01 00:00:00

abstract：:The paper introduces evaluation methodologies and associated statistical approaches for process validation lifecycle Stage 3A. The assessment tools proposed can be applied to newly developed and launched small molecule as well as bio-pharma products, where substantial process and product knowledge has been gathered. T...

journal_title：AAPS PharmSciTech

authors： Sayeed-Desta N,Pazhayattil AB,Collins J,Chen S,Ingram M,Spes J

更新日期：2017-07-01 00:00:00

abstract：:We determined the permeability coefficient of a model hydrophilic drug, calcein, encapsulated within saturated lipid-based nano-sized liposomes of various lipid profiles. We demonstrated that the addition of cholesterol to liposomes containing saturated lipids increased the permeability of the liposomal membrane to ca...

journal_title：AAPS PharmSciTech

authors： Takechi-Haraya Y,Sakai-Kato K,Goda Y

更新日期：2017-07-01 00:00:00

abstract：:Loteprednol etabonate (LE) is a soft corticosteroid that maintains therapeutic activity with much reduced adverse effects. Yet, its ocular bioavailability is hindered by its poor aqueous solubility. Early attempts of LE complexation with cyclodextrins (CDs) did not involve the study of the effects of various complexat...

journal_title：AAPS PharmSciTech

authors： Soliman OAE,Mohamed EAM,El-Dahan MS,Khatera NAA

更新日期：2017-05-01 00:00:00

abstract：:Nanotechnology is having a significant impact in the drug delivery systems and diagnostic devices. As most of the nanosystems are intended to be administered in vivo, there is a need for stability models, which could simulate the biological environment. Instability issues could lead to particle aggregation and in turn...

journal_title：AAPS PharmSciTech

authors： Shaikh MV,Kala M,Nivsarkar M

更新日期：2017-05-01 00:00:00

abstract：:The current study aimed to develop a prolonged-release pramipexole (PPX) transdermal patch for the treatment of Parkinson's disease. Permeation parameters of PPX were investigated using human cadaver skin. Pramipexole patches were prepared using DURO-TAK® pressure-sensitive-adhesive (PSA) and evaluated for drug stabil...

journal_title：AAPS PharmSciTech

authors： Pu T,Li X,Sun Y,Ding X,Pan Y,Wang Q

更新日期：2017-04-01 00:00:00

abstract：:The aim of this study is to develop an orally disintegrating film (ODF) containing a microparticulate measles vaccine formulation for buccal delivery. The measles vaccine microparticles were made with biocompatible and biodegradable bovine serum albumin (BSA) and processed by spray drying. These vaccine microparticles...

journal_title：AAPS PharmSciTech

authors： Gala RP,Popescu C,Knipp GT,McCain RR,Ubale RV,Addo R,Bhowmik T,Kulczar CD,D'Souza MJ

更新日期：2017-02-01 00:00:00

abstract：:Colorectal cancer is a global concern, and its treatment is fraught with non-selective effects including adverse side effects requiring hospital visits and palliative care. A relatively safe drug formulated in a bioavailability enhancing and targeting delivery platform will be of significance. Metformin-loaded solid l...

journal_title：AAPS PharmSciTech

authors： Ngwuluka NC,Kotak DJ,Devarajan PV

更新日期：2017-02-01 00:00:00

abstract：:Children frequently receive medicines that are designed for adults. The dose of commercially available products is adapted, mostly based on the child's bodyweight, thereby neglecting differences in pharmacokinetic and pharmacodynamics parameters. If commercial products are unsuitable for administration to children or ...

journal_title：AAPS PharmSciTech

authors： Visser JC,Woerdenbag HJ,Hanff LM,Frijlink HW

更新日期：2017-02-01 00:00:00

abstract：:Nanostructured lipid carriers (NLCs) are interesting delivery systems for enhancing the penetration of an active substance through the skin after topical administration. The present paper described the development of a novel NLCs for minoxidil (MXD) topical delivery. Stearic acid and oleic acid that showed the highest...

journal_title：AAPS PharmSciTech

authors： Wang W,Chen L,Huang X,Shao A

更新日期：2017-02-01 00:00:00

abstract：:Posaconazole is a triazole antifungal drug that with extremely poor aqueous solubility. Up to now, this drug can be administered via intravenous injection and oral suspension. However, its oral bioavailability is greatly limited by the dissolution rate of the drug. This study aimed to improve water solubility and diss...

journal_title：AAPS PharmSciTech

authors： Tang P,Wang L,Ma X,Xu K,Xiong X,Liao X,Li H

更新日期：2017-01-01 00:00:00

abstract：:Piroxicam is used in the treatment of rheumatoid arthritis, osteoarthritis, and other inflammatory diseases. Upon oral administration, it is reported to cause ulcerative colitis, gastrointestinal irritation, edema and peptic ulcer. Hence, an alternative delivery system has been designed in the form of transethosome. T...

journal_title：AAPS PharmSciTech

authors： Garg V,Singh H,Bhatia A,Raza K,Singh SK,Singh B,Beg S

更新日期：2017-01-01 00:00:00

abstract：:In this study the stability of parenteral acyclovir (ACV) when diluted in dextrose (DEX) as large volume intravenous fluid preparation (LVIF) was evaluated and the possible Maillard reaction adducts were monitored in the recommended infusion time. Different physicochemical methods were used to evaluate the Maillard re...

journal_title：AAPS PharmSciTech

authors： Siahi Shadbad MR,Ghaderi F,Hatami L,Monajjemzadeh F

更新日期：2016-12-01 00:00:00

abstract：:Effectiveness of CNS-acting drugs depends on the localization, targeting, and capacity to be transported through the blood-brain barrier (BBB) which can be achieved by designing brain-targeting delivery vectors. Hence, the objective of this study was to screen the formulation and process variables affecting the perfor...

journal_title：AAPS PharmSciTech

authors： Harbi I,Aljaeid B,El-Say KM,Zidan AS

更新日期：2016-12-01 00:00:00

abstract：:The interactions with and effects of five chemically distinct, bioactive phenolic compounds on the lipid bilayers of model dipalmitoylphosphatidylcholine (DPPC) liposomes were investigated. Complementary analytical techniques, including differential scanning calorimetry (DSC) and phosphorus and proton nuclear magnetic...

journal_title：AAPS PharmSciTech

authors： Malekar SA,Sarode AL,Bach AC 2nd,Worthen DR

更新日期：2016-12-01 00:00:00

abstract：:Our objective was to prepare nanoparticulate system using a simple yet attractive innovated method as an ophthalmic delivery system for fluocinolone acetonide to improve its ocular bioavailability. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles were prepared by adopting thin film hydration method using PLGA/poloxa...

journal_title：AAPS PharmSciTech

authors： Salama AH,Mahmoud AA,Kamel R

更新日期：2016-10-01 00:00:00

abstract：:Helicobacter pylori infection remains challenging as it mainly colonized beneath the deep gastric mucosa and adheres to epithelial cells of the stomach. Concanavalin-A (Con-A)-conjugated gastro-retentive poly (lactic-co-glycolic acid) (PLGA) nanoparticles of acetohydroxamic acid (AHA) and clarithromycin (CLR) were pre...

journal_title：AAPS PharmSciTech

authors： Jain SK,Haider T,Kumar A,Jain A

更新日期：2016-10-01 00:00:00

abstract：:A hydroxyethylcellulose-poly(acrylic acid) (HEC-PAA) lyomatrix was developed for ganciclovir (GCV) intestine targeting to overcome its undesirable degradation in the stomach. GCV was encapsulated within the HEC-PAA lyomatrix prepared by lyophilization. Conventional tablets were also prepared with identical GCV concent...

journal_title：AAPS PharmSciTech

authors： Mabrouk M,Mulla JA,Kumar P,Chejara DR,Badhe RV,Choonara YE,du Toit LC,Pillay V

更新日期：2016-10-01 00:00:00

abstract：:Current pharmacopeial methods for in vitro orally inhaled product (OIP) performance testing were developed primarily to support requirements for drug product registration and quality control. In addition, separate clinical studies are undertaken in order to quantify safety and efficacy in the hands of the patient. How...

journal_title：AAPS PharmSciTech

authors： Mitchell JP,Suggett J,Nagel M

更新日期：2016-08-01 00:00:00

abstract：:The solvent used for preparing the binder solution in wet granulation can affect the granulation end point and also impact the thermal, rheological, and flow properties of the granules. The present study investigates the effect of solvents and percentage relative humidity (RH) on the granules of microcrystalline cellu...

journal_title：AAPS PharmSciTech

authors： Jagia M,Trivedi M,Dave RH

更新日期：2016-08-01 00:00:00

abstract：:The oxidation of glucagon by the H2O2/Cu(2+) system and by simulated sunlight was studied using HPLC-MS methodologies. It was found that copper ion-catalyzed oxidation is much faster in the residue 1-12 region than in photo-oxidation, but it is slower than photo-oxidation in the residue 18-29 region. This difference i...

journal_title：AAPS PharmSciTech

authors： Zhang J

更新日期：2016-08-01 00:00:00

abstract：:The approach documented in this article reviews data from earlier process validation lifecycle stages with a described statistical model to provide the "best estimate" on the number of process performance qualification (PPQ) batches that should generate sufficient information to make a scientific and risk-based decisi...

journal_title：AAPS PharmSciTech

authors： Pazhayattil A,Alsmeyer D,Chen S,Hye M,Ingram M,Sanghvi P

更新日期：2016-08-01 00:00:00

abstract：:An extract of Zingiber cassumunar Roxb. (ZC) was encapsulated in niosomes of which a topical gel was formed. (E)-4-(3',4'-dimethoxyphenyl)but-3-en-1-ol or compound D detected by a gradient HPLC was employed as the marker and its degradation determined to follow zero-order kinetics. Niosomes significantly retarded ther...

journal_title：AAPS PharmSciTech

authors： Priprem A,Janpim K,Nualkaew S,Mahakunakorn P

更新日期：2016-06-01 00:00:00

abstract：:The objective of this study was to prepare and evaluate terbutaline sulphate (TBS) bi-layer tablets for once-daily administration. The bi-layer tablets consisted of an immediate-release layer and a sustained-release layer containing 5 and 10 mg TBS, respectively. The sustained-release layer was developed by using Comp...

journal_title：AAPS PharmSciTech

authors： Hashem FM,Nasr M,Fathy G,Ismail A

更新日期：2016-06-01 00:00:00

abstract：:To enhance the stability of coenzyme Q10 (CoQ10), Kolliphor® HS 15 (HS15) was employed as a carrier to build up a stable CoQ10-loaded micelle delivery system. The impact of micellar compositions, the preparation condition, and the preparation method on size characteristics, the solubilization efficiency, and micellar ...

journal_title：AAPS PharmSciTech

authors： Liu L,Mao K,Wang W,Pan H,Wang F,Yang M,Liu H

更新日期：2016-06-01 00:00:00

abstract：:Capsaicin has multiple pharmacological activities including antioxidant, anticancer, and anti-inflammatory activities. However, its clinical application is limited due to its poor aqueous solubility, gastric irritation, and low oral bioavailability. This research was aimed at preparing sustained-release matrix pellets...

journal_title：AAPS PharmSciTech

authors： Zhang Y,Huang Z,Omari-Siaw E,Lu S,Zhu Y,Jiang D,Wang M,Yu J,Xu X,Zhang W

更新日期：2016-04-01 00:00:00

abstract：:Successful pellet production has been reported in literature with cross-linked poly(vinylpyrrolidone), Polyplasdone® XL-10 and INF-10. In the present study, a quality by experimental design approach was used to assess several formulation and process parameter effects on the characteristics of Polyplasdone® XL-10 pelle...

journal_title：AAPS PharmSciTech

authors： Saripella KK,Loka NC,Mallipeddi R,Rane AM,Neau SH

更新日期：2016-04-01 00:00:00

abstract：:The solubility of five poorly soluble drugs was enhanced by using an effervescence assisted solid dispersion (EASD) technique. EASDs were prepared by using modified fusion method. Drug and hydrophilic carrier were melted, and in this molten mixture, effervescence was generated by adding effervescence couple comprising...

journal_title：AAPS PharmSciTech

authors： Alam MA,Al-Jenoobi FI,Al-Mohizea AM,Ali R

更新日期：2015-12-01 00:00:00

abstract：:The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often ter...

journal_title：AAPS PharmSciTech

authors： Patil SS,Venugopal E,Bhat S,Mahadik KR,Paradkar AR

更新日期：2015-10-01 00:00:00

abstract：:Pneumocystis carinii pneumonia (PCP) is a major opportunistic infection that affects patients with human immunodeficiency virus. Although orally administered dapsone leads to high hepatic metabolism, decreasing the therapeutic index and causing severe side effects, this drug is an effective alternative for the treatme...

journal_title：AAPS PharmSciTech

authors： Ortiz M,Jornada DS,Pohlmann AR,Guterres SS

更新日期：2015-10-01 00:00:00

abstract：:The objective of the present study is to investigate the confounding effects, if any, of beta-cyclodextrins (βCDs) on corneal permeability coefficients obtained from in vitro transmembrane diffusion studies. Transcorneal permeability studies were carried out with 2-hydroxypropyl-beta-cyclodextrin (HPβCD) and randomly ...

journal_title：AAPS PharmSciTech

authors： Adelli GR,Balguri SP,Majumdar S

更新日期：2015-10-01 00:00:00

abstract：:Developing amorphous solid dispersions of water-insoluble molecules using polymeric materials is a well-defined approach to improve the dissolution rate and bioavailability. While the selected polymer plays a vital role in stabilizing the amorphous solid dispersion physically, it is equally important to improve the di...

journal_title：AAPS PharmSciTech

authors： Verma S,Rudraraju VS

更新日期：2015-10-01 00:00:00

abstract：:In this study, the use of trimethylchitosan (TMC), by higher solubility in comparison with chitosan, in alginate/chitosan nanoparticles containing cationic β-cyclodextrin polymers (CPβCDs) has been studied, with the aim of increasing insulin uptake by nanoparticles. Firstly, TMCs were synthesized by iodomethane, and C...

journal_title：AAPS PharmSciTech

authors： Mansourpour M,Mahjub R,Amini M,Ostad SN,Shamsa ES,Rafiee-Tehrani M,Dorkoosh FA

更新日期：2015-08-01 00:00:00

abstract：:The present work was undertaken with the objectives of improving the dissolution velocity, related oral bioavailability, and minimizing the fasted/fed state variability of repaglinide, a poorly water-soluble anti-diabetic active by exploring the principles of nanotechnology. Nanocrystal formulations were prepared by b...

journal_title：AAPS PharmSciTech

authors： Gadadare R,Mandpe L,Pokharkar V

更新日期：2015-08-01 00:00:00

abstract：:The influence of alkaline and the neutral grade of magnesium aluminometasilicate as a porous solid carrier for the liquid self-emulsifying formulation with ibuprofen is investigated. Ibuprofen is dissolved in Labrasol, then this solution is adsorbed on the silicates. The drug to the silicate ratio is 1:2, 1:4, and 1:6...

journal_title：AAPS PharmSciTech

authors： Krupa A,Szlęk J,Jany BR,Jachowicz R

更新日期：2015-06-01 00:00:00

abstract：:Kinetic methods for accurate determination of nortriptyline hydrochloride have been described. The methods are based on the oxidation of nortriptyline hydrochloride with KMnO4 in acidic and basic media. In acidic medium, the decrease in absorbance at 525.5 nm and in basic medium, the increase in absorbance at 608.5 nm...

journal_title：AAPS PharmSciTech

authors： Rahman N,Khan S

更新日期：2015-06-01 00:00:00

abstract：:Non-invasive administration of insulin is expected for better diabetes mellitus therapy. In this report, we developed intraoral preparation for insulin. Insulin was encapsulated into nanocarrier using self-assembly emulsification process. To increase lipophilicity of insulin, it was dispersed in phospholipid resulted ...

journal_title：AAPS PharmSciTech

authors： Rachmawati H,Haryadi BM,Anggadiredja K,Suendo V

更新日期：2015-06-01 00:00:00

abstract：:The objective of this study was to determine the influence of mechanical stresses simulating gastrointestinal contraction forces of 2.0 N (stomach) and 1.2 N (intestine) on the gel properties and drug release characteristics from sustained release swelling and eroding hydrophilic matrices during dissolution studies. T...

journal_title：AAPS PharmSciTech

authors： Takieddin M,Fassihi R

更新日期：2015-04-01 00:00:00

abstract：:The objective of the present study was to investigate the effects of processing variables and formulation factors on the characteristics of hot-melt extrudates containing a copolymer (Kollidon® VA 64). Nifedipine was used as a model drug in all of the extrudates. Differential scanning calorimetry (DSC) was utilized on...

journal_title：AAPS PharmSciTech

authors： Maddineni S,Battu SK,Morott J,Majumdar S,Murthy SN,Repka MA

更新日期：2015-04-01 00:00:00

abstract：:The current study explains the development of sorbitan monostearate and sesame oil-based organogels for topical drug delivery. The organogels were prepared by dissolving sorbitan monostearate in sesame oil (70°C). Metronidazole was used as a model antimicrobial. The formulations were characterized using phase contrast...

journal_title：AAPS PharmSciTech

authors： Singh VK,Pramanik K,Ray SS,Pal K

更新日期：2015-04-01 00:00:00